Sedation Depth and Long-Term Mortality in ventilated adults
Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study.
Shehabi Y, Chan L, Kadiman S, Alias A, Ismail WN, Tan MA, Khoo TM, Ali SB, Saman MA, Shaltut A, Tan CC, Yong CY, Bailey M; Sedation Practice in Intensive Care Evaluation (SPICE) Study Group investigators.
In mechanically ventilated critically ill patients with mainly medical ICU admission diagnoses, the intensity of sedation in the first 48 h after initiation of mechanical ventilation was independently associated with time to extubation and mortality.
These findings strengthen the premise that early sedation depth is a potentially modifiable target to improve important clinical outcomes and a universal problem in intensive care sedation worldwide.
Intensive Care Med. 2013 May;39(5):910-8. doi: 10.1007/s00134-013-2830-2
Full Text Article at: https://link.springer.com/content/pdf/10.1007%2Fs00134-013-2830-2.pdf
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