Sedation Depth and Long-Term Mortality in ventilated adults

Sedation Depth and Long-Term Mortality in ventilated adults

Deep Sedation


Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study.

Shehabi Y, Chan L, Kadiman S, Alias A, Ismail WN, Tan MA, Khoo TM, Ali SB, Saman MA, Shaltut A, Tan CC, Yong CY, Bailey M; Sedation Practice in Intensive Care Evaluation (SPICE) Study Group investigators.

In mechanically ventilated critically ill patients with mainly medical ICU admission diagnoses, the intensity of sedation in the first 48 h after initiation of mechanical ventilation was independently associated with time to extubation and mortality.

These findings strengthen the premise that early sedation depth is a potentially modifiable target to improve important clinical outcomes and a universal problem in intensive care sedation worldwide.

2013 May;39(5):910-8. doi: 10.1007/s00134-013-2830-2


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